# References — Cognitive & Nootropic Peptide Literature — Chai Peptide

> The aggregated citation list for the Chai Peptide cognitive research digest: peer-reviewed sources on DSIP and Semax, with DOIs and PubMed links.

Every source cited across the DSIP and Semax pages and the comparison, gathered in one place.

## References

The list below aggregates the cited literature across both peptides on this desk — DSIP and Semax. Each entry gives authors, title, journal and year, with a DOI and a PubMed link where available. A citation is listed once and referred to by its number throughout the site.

## References

[1] Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Front Pharmacol. 2024;15:1439536. https://pubmed.ncbi.nlm.nih.gov/39444618/
[2] Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. https://pubmed.ncbi.nlm.nih.gov/16539679/
[3] Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. https://pubmed.ncbi.nlm.nih.gov/12782416/
[4] Bjartell A, Ekman R, Bergquist S, Widerlov E. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. https://pubmed.ncbi.nlm.nih.gov/2554357/
[5] Schneider-Helmert D, et al. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(8):913-914. https://pubmed.ncbi.nlm.nih.gov/7028502/
[6] et al. Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol. 2025. https://pubmed.ncbi.nlm.nih.gov/40692165/
[7] Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014;15:228. https://pubmed.ncbi.nlm.nih.gov/24661604/
[8] Agapova TY, et al. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH(4-10). Neurosci Lett. 2007;417(2):201-5. https://pubmed.ncbi.nlm.nih.gov/17353092/
[9] Dolotov OV, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006;97 Suppl 1:82-6. https://pubmed.ncbi.nlm.nih.gov/16635254/
[10] Romanova GA, et al. Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex. Bull Exp Biol Med. 2006;142(6):663-6. https://pubmed.ncbi.nlm.nih.gov/17603664/
[11] Shevchenko KV, et al. Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration. Russ J Bioorg Chem (Bioorg Khim). 2006;32(1):57-62. https://pubmed.ncbi.nlm.nih.gov/16523722/
[12] Kost NV, et al. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorg Khim (Russ J Bioorg Chem). 2001;27(3):180-183. https://pubmed.ncbi.nlm.nih.gov/11443939/

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